A turn-on fluorescent sensor for the discrimination of cystein from homocystein and glutathione

Li-Ya Niu; Ying-Shi Guan; Yu-Zhe Chen; Li-Zhu Wu; Chen-Ho Tung; Qing-Zheng Yang

doi:10.1039/c2cc38429a

A turn-on fluorescent sensor for the discrimination of cystein from homocystein and glutathione

Chem Commun (Camb). 2013 Feb 14;49(13):1294-6. doi: 10.1039/c2cc38429a. Epub 2013 Jan 8.

Authors

Li-Ya Niu¹, Ying-Shi Guan, Yu-Zhe Chen, Li-Zhu Wu, Chen-Ho Tung, Qing-Zheng Yang

Affiliation

¹ Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, PR China.

PMID: 23295243
DOI: 10.1039/c2cc38429a

Abstract

We report a turn-on fluorescent sensor based on nitrothiophenolate boron dipyrromethene (BODIPY) derivatives for the discrimination of cystein (Cys) from homocystein (Hcy) and glutathione (GSH). The sensor was applied for detection of Cys in living cells.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cysteine / analysis*
Cysteine / chemistry*
Glutathione / analysis*
Glutathione / chemistry*
HeLa Cells
Homocysteine / analysis*
Homocysteine / chemistry*
Humans
Spectrometry, Fluorescence
Sulfhydryl Compounds / chemistry

Substances

Sulfhydryl Compounds
Homocysteine
Glutathione
Cysteine