Origins and significance of astrogliosis in the multiple sclerosis model, MOG peptide EAE

J Neurol Sci. 2013 Oct 15;333(1-2):55-9. doi: 10.1016/j.jns.2012.12.014. Epub 2013 Jan 5.

Abstract

Astroglia, the most abundant cells in the human CNS, and even more prominent in multiple sclerosis patients, participate in CNS innate and adaptive immunity, and have been hypothesized to play an important role in multiple sclerosis progression. Experimental autoimmune encephalomyelitis elicited in mice by immunization with myelin oligodendrocyte glycoprotein peptide 35-55 provides a means by which to explore the genesis and disease significance of astrogliosis during a chronic immune-mediated CNS inflammatory/demyelinative disorder that, in its' pathological features, strongly resembles multiple sclerosis.

Keywords: Astroglia; Experimental autoimmune encephalomyelitis; Multiple sclerosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Astrocytes / immunology
  • Astrocytes / physiology*
  • Disease Models, Animal
  • Encephalomyelitis, Autoimmune, Experimental / chemically induced
  • Encephalomyelitis, Autoimmune, Experimental / immunology
  • Encephalomyelitis, Autoimmune, Experimental / pathology
  • Encephalomyelitis, Autoimmune, Experimental / physiopathology*
  • Gliosis / chemically induced
  • Gliosis / immunology
  • Gliosis / pathology*
  • Humans
  • Models, Biological*
  • Multiple Sclerosis / immunology
  • Multiple Sclerosis / pathology*
  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments

Substances

  • Myelin-Oligodendrocyte Glycoprotein
  • Peptide Fragments
  • myelin oligodendrocyte glycoprotein (35-55)