Preparation, preliminary screening of new types of steroid conjugates and their activities on steroid receptors

Steroids. 2013 Mar;78(3):356-61. doi: 10.1016/j.steroids.2012.11.016. Epub 2013 Jan 4.

Abstract

There were synthesized new types of ribbon type steroidal dimers derived from three types of steroidal skeletons (cholic acid, etienic acid, estrone) using Cu(I) catalyzed 1, 3-dipolar cycloaddition reaction. Steroid parts of the molecular "ribbons" are linked by heterocyclic moiety, namely by 2,6-bis((1H-1,2,3-triazol-1-yl)-methyl)pyridine. Compounds synthesized possess different cytotoxic and hormone receptor modulating activities.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Androstenes / chemistry*
  • Catalysis
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cholic Acid / chemistry*
  • Cytotoxins / chemical synthesis*
  • Cytotoxins / pharmacology
  • Estrone / chemistry*
  • Hormone Antagonists / chemical synthesis*
  • Hormone Antagonists / pharmacology
  • Humans
  • Molecular Structure
  • Pyridines / chemistry
  • Receptors, Steroid / antagonists & inhibitors
  • Receptors, Steroid / metabolism
  • Steroids / chemical synthesis*
  • Steroids / pharmacology
  • Structure-Activity Relationship

Substances

  • Androstenes
  • Cytotoxins
  • Hormone Antagonists
  • Pyridines
  • Receptors, Steroid
  • Steroids
  • Estrone
  • etienic acid
  • Cholic Acid