PXR polymorphisms interacted with CYP2B6 polymorphisms on methadone metabolites

J Clin Psychopharmacol. 2013 Feb;33(1):137-40. doi: 10.1097/01.jcp.0000426186.34421.de.
No abstract available

Publication types

  • Letter
  • Multicenter Study

MeSH terms

  • Analgesics, Opioid / blood
  • Analgesics, Opioid / pharmacokinetics*
  • Analgesics, Opioid / therapeutic use
  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Biotransformation
  • Cytochrome P-450 CYP2B6
  • Gene Frequency
  • Genotype
  • Heroin Dependence / blood
  • Heroin Dependence / rehabilitation*
  • Humans
  • Linear Models
  • Linkage Disequilibrium
  • Liver / enzymology*
  • Methadone / blood
  • Methadone / pharmacokinetics*
  • Methadone / therapeutic use
  • Opiate Substitution Treatment*
  • Oxidoreductases, N-Demethylating / genetics*
  • Oxidoreductases, N-Demethylating / metabolism
  • Pharmacogenetics
  • Phenotype
  • Polymorphism, Single Nucleotide*
  • Pregnane X Receptor
  • Receptors, Steroid / genetics*
  • Receptors, Steroid / metabolism
  • Taiwan

Substances

  • Analgesics, Opioid
  • Pregnane X Receptor
  • Receptors, Steroid
  • Aryl Hydrocarbon Hydroxylases
  • CYP2B6 protein, human
  • Cytochrome P-450 CYP2B6
  • Oxidoreductases, N-Demethylating
  • Methadone

Associated data

  • ClinicalTrials.gov/NCT01059747