Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein

Siming Chen; Huan Jiang; Kaiju Wei; Yangzhong Liu

doi:10.1039/c2cc38517a

Tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein

Chem Commun (Camb). 2013 Feb 11;49(12):1226-8. doi: 10.1039/c2cc38517a. Epub 2013 Jan 4.

Authors

Siming Chen¹, Huan Jiang, Kaiju Wei, Yangzhong Liu

Affiliation

¹ CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, 230026 Hefei, Anhui, China.

PMID: 23288105
DOI: 10.1039/c2cc38517a

Abstract

A widely used reducing agent tris-(2-carboxyethyl) phosphine significantly promotes the reaction of cisplatin with Sp1 zinc finger protein. This discovery clarifies the reactivity of cisplatin towards Sp1 zinc finger protein and implies that the reactions of platinum drugs could be largely influenced by small molecules with a strong trans effect.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cisplatin / chemistry*
Isomerism
Oxidation-Reduction
Phosphines / chemistry*
Sp1 Transcription Factor / chemistry*
Sp1 Transcription Factor / metabolism

Substances

Phosphines
Sp1 Transcription Factor
phosphine
Cisplatin