Giant condyloma of the cervix: an uncommon entity associated with low-risk human papilloma virus infection

Am J Surg Pathol. 2013 Feb;37(2):300-4. doi: 10.1097/PAS.0b013e31826d261e.

Abstract

"Giant Condylomas" of the cervix are very uncommon, and have not been fully characterized in the English literature. We report 4 cases of cervical giant condyloma seen in our practice. Patients were predominantly young and presented with a cervical lesion producing bleeding or a mass effect. Biopsy/excision revealed a uniformly bland, exophytic squamous epithelial proliferation with viral cytopathic changes and absence of stromal invasion. Human papilloma virus types 6 and 11 were detected in all cases. Follow-up was uneventful without recurrence or spread. Giant condylomas of the cervix as defined in this report signify a benign albeit extensive variant of low-risk human papilloma virus infection. This term is proposed as a specific descriptor for such lesions and should be considered in the setting of any large well-differentiated exophytic cervical squamous lesion in young or immunosuppressed women. The term "giant condyloma of Buschke and Loewenstein" should be discontinued given the lack of specificity.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged, 80 and over
  • Buschke-Lowenstein Tumor / pathology*
  • Buschke-Lowenstein Tumor / virology
  • Cervix Uteri / pathology
  • Diagnosis, Differential
  • Fatal Outcome
  • Female
  • Human papillomavirus 11 / isolation & purification
  • Human papillomavirus 6 / isolation & purification
  • Humans
  • Magnetic Resonance Imaging
  • Metaplasia / diagnosis
  • Papillomavirus Infections / complications
  • Papillomavirus Infections / pathology*
  • Pregnancy
  • Pregnancy Complications, Neoplastic*
  • Premenopause
  • Uterine Cervical Diseases / diagnosis
  • Uterine Cervical Neoplasms / pathology*
  • Uterine Cervical Neoplasms / virology