Isolation, characterization, and bioactivity evaluation of 3-((6-methylpyrazin-2-yl)methyl)-1H-indole, a new alkaloid from a deep-sea-derived actinomycete Serinicoccus profundi sp. nov

Mar Drugs. 2012 Dec 27;11(1):33-9. doi: 10.3390/md11010033.

Abstract

One new alkaloid, 3-((6-methylpyrazin-2-yl)methyl)-1H-indole (1) was obtained from the deep-sea actinomycete Serinicoccus profundi sp. nov., along with five known compounds (2-6). Their structures were determined on the basis of detailed analysis of the 1D and 2D NMR as well as MS data. The new indole alkaloid displayed weak antimicrobial activity against Staphylococcus aureus ATCC 25923 with an MIC value of 96 μg/mL. It showed no cytotoxicity on a normal human liver cell line (BEL7402) and a human liver tumor cell line (HL-7702).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actinomycetales / chemistry*
  • Actinomycetales / isolation & purification
  • Actinomycetales / metabolism
  • Cell Line
  • Cell Line, Tumor
  • Humans
  • Indole Alkaloids / chemistry*
  • Indole Alkaloids / isolation & purification*
  • Indole Alkaloids / pharmacology
  • Magnetic Resonance Spectroscopy / methods
  • Microbial Sensitivity Tests / methods
  • Oceans and Seas
  • Seawater / microbiology*
  • Staphylococcus aureus / drug effects

Substances

  • Indole Alkaloids