Sudden atelectasis and respiratory failure in a neutropenic patient: atypical presentation of pseudomembranous necrotizing bronchial aspergillosis

Korean J Intern Med. 2012 Dec;27(4):463-6. doi: 10.3904/kjim.2012.27.4.463. Epub 2012 Nov 27.

Abstract

Pseudomembranous necrotizing bronchial aspergillosis (PNBA) is a rare form of invasive aspergillosis with a very poor prognosis. The symptoms are non-specific, and the necrotizing plugs cause airway obstruction. Atelectasis and respiratory failure can be the initial manifestations. Recently, we treated an immunocompromised patient with PNBA, who presented with a sudden onset of atelectasis and acute respiratory failure. There were no preceding signs except for a mild cough and one febrile episode. Bronchoscopy revealed PNBA, and Aspergillus nidulans was cultured from the bronchial wash.

Keywords: Aspergillosis; Neutropenia; Pneumonia.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Female
  • Humans
  • Immunocompromised Host
  • Invasive Pulmonary Aspergillosis / complications*
  • Invasive Pulmonary Aspergillosis / diagnosis*
  • Leukemia, Myeloid, Acute / complications
  • Neutropenia / complications
  • Pulmonary Atelectasis / etiology*
  • Respiratory Insufficiency / etiology*