Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents

Jian-Li Shang; Hui Guo; Zai-Shun Li; Biao Ren; Zheng-Ming Li; Huan-qin Dai; Li-Xin Zhang; Jian-Guo Wang

doi:10.1016/j.bmcl.2012.11.103

Synthesis and evaluation of novel sulfenamides as novel anti Methicillin-resistant Staphylococcus aureus agents

Bioorg Med Chem Lett. 2013 Feb 1;23(3):724-7. doi: 10.1016/j.bmcl.2012.11.103. Epub 2012 Dec 3.

Authors

Jian-Li Shang¹, Hui Guo, Zai-Shun Li, Biao Ren, Zheng-Ming Li, Huan-qin Dai, Li-Xin Zhang, Jian-Guo Wang

Affiliation

¹ State-Key Laboratory and Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PR China.

PMID: 23265879
DOI: 10.1016/j.bmcl.2012.11.103

Abstract

A total of 29 novel sulfenamide compounds were synthesized, spectroscopically characterized and evaluated in vitro for antimicrobial activity against various infectious pathogens. Compounds 1b and 2c exhibited potent inhibition against clinical Methicillin-resistant Staphylococcus aureus (MRSA) strains with minimum inhibitory concentration (MIC) values of 1.56 μg/mL.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Methicillin-Resistant Staphylococcus aureus / drug effects*
Microbial Sensitivity Tests
Molecular Structure
Sulfamerazine / chemical synthesis*
Sulfamerazine / chemistry
Sulfamerazine / pharmacology*

Substances

Anti-Bacterial Agents
sulfenamide
Sulfamerazine