Multivalent glyco(cyclo)peptides

Chem Soc Rev. 2013 Jun 7;42(11):4599-612. doi: 10.1039/c2cs35413f. Epub 2012 Dec 21.

Abstract

Because of the importance of carbohydrate-protein interactions in biological processes, the development of glycoclusters and glycodendrimers capable of mimicking the multivalent display of carbohydrates at the cell surface has become a major field of research over the last decade. Among the large variety of scaffolds that are now available, peptides and cyclopeptides are widely used for the multivalent presentation of glycans. This review will provide an overview of the most recent advances in the preparation and utilization of linear glycopeptides and glycocyclopeptides in glycobiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / immunology
  • Carbohydrates / chemistry
  • Glycopeptides / chemistry
  • Glycopeptides / metabolism*
  • Glycosylation
  • Ligands
  • Mucins / chemistry
  • Mucins / metabolism
  • Vaccines, Synthetic / biosynthesis
  • Vaccines, Synthetic / chemistry
  • Vaccines, Synthetic / immunology

Substances

  • Antineoplastic Agents
  • Carbohydrates
  • Glycopeptides
  • Ligands
  • Mucins
  • Vaccines, Synthetic