In this article, a 3-D finite element (FE) model of human pelvic with a modular hemi-pelvic prosthesis was constructed to study the effect of screw fixation type on the biomechanics of the prosthesis. The results showed that the elimination of the screw far away from the pelvic arcuate line did not induce the instability and stress increase in the prosthesis. On the contrary, some stress in the sustain and acetabular parts decreased by 26.4% and 11.4%, respectively. In conclusion, the optimization of screw fixation can maintain the prosthesis stability and reduced stress concentration on some prosthesis parts. It was deduced that the optimization of the prosthesis could help surgeon reconstruct the pelvic joint function better and diminish the clinical time and cost.