Abstract
Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC(50) of 23.7 nM.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Drug Screening Assays, Antitumor
-
Humans
-
Hydrocarbons, Iodinated / chemistry
-
Hydrocarbons, Iodinated / isolation & purification*
-
Hydrocarbons, Iodinated / pharmacology
-
Korea
-
Marine Biology
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Organophosphorus Compounds / chemistry
-
Organophosphorus Compounds / isolation & purification*
-
Organophosphorus Compounds / pharmacology
-
PPAR delta / agonists*
-
Polyynes / chemistry
-
Polyynes / isolation & purification*
-
Polyynes / pharmacology
-
Porifera / chemistry*
Substances
-
Hydrocarbons, Iodinated
-
Organophosphorus Compounds
-
PPAR delta
-
phosphoiodyn A
-
phosphoiodyn B
-
Polyynes