Phosphoiodyns A and B, unique phosphorus-containing iodinated polyacetylenes from a Korean sponge Placospongia sp

Org Lett. 2013 Jan 4;15(1):100-3. doi: 10.1021/ol3031318. Epub 2012 Dec 14.

Abstract

Two unprecedented phosphorus-containing iodinated polyacetylenes, phosphoiodyns A and B (1-2), were isolated from a Korean marine sponge Placospongia sp. Their structures were elucidated by spectroscopic data analysis. Phosphoiodyn A exhibited potent agonistic activity on human peroxisome proliferator-activated receptor delta (hPPARδ) with an EC(50) of 23.7 nM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydrocarbons, Iodinated / chemistry
  • Hydrocarbons, Iodinated / isolation & purification*
  • Hydrocarbons, Iodinated / pharmacology
  • Korea
  • Marine Biology
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Organophosphorus Compounds / chemistry
  • Organophosphorus Compounds / isolation & purification*
  • Organophosphorus Compounds / pharmacology
  • PPAR delta / agonists*
  • Polyynes / chemistry
  • Polyynes / isolation & purification*
  • Polyynes / pharmacology
  • Porifera / chemistry*

Substances

  • Hydrocarbons, Iodinated
  • Organophosphorus Compounds
  • PPAR delta
  • phosphoiodyn A
  • phosphoiodyn B
  • Polyynes