Migracins A and B, new inhibitors of cancer cell migration, produced by Streptomyces sp

J Antibiot (Tokyo). 2013 Apr;66(4):225-30. doi: 10.1038/ja.2012.112. Epub 2012 Dec 12.

Abstract

In the course of screening for breast cancer cell migration inhibitors, we isolated two novel compounds, migracins A and B from the culture broth of Streptomyces sp. MI264-NF2. Their structures are related to those of luminacins previously isolated from Streptomyces. Migracins A and B inhibited breast cancer cell migration, monitored by wound healing assay with IC50 values of 1.31 and 1.99 μg ml(-1), respectively, in human breast carcinoma MDA-MB-231 cells without showing any cytotoxicity. Migracins also inhibited the migration of human lung adenocarcinoma A549 cells and human fibrosarcoma HT-1080 cells. Therefore, migracins may become new cancer metastasis inhibitors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Antibiotics, Antineoplastic / isolation & purification*
  • Antibiotics, Antineoplastic / pharmacology
  • Benzaldehydes / isolation & purification*
  • Benzaldehydes / pharmacology
  • Breast Neoplasms / drug therapy
  • Cell Line, Tumor
  • Cell Movement / drug effects*
  • Female
  • Fibrosarcoma / drug therapy
  • Humans
  • Lung Neoplasms / drug therapy
  • NF-kappa B / antagonists & inhibitors
  • Neoplasm Metastasis / drug therapy*
  • Streptomyces / metabolism*

Substances

  • Antibiotics, Antineoplastic
  • Benzaldehydes
  • NF-kappa B
  • migracin A
  • migracin B