BODIPY-phosphane as a versatile tool for easy access to new metal-based theranostics

Dalton Trans. 2013 May 7;42(17):6102-9. doi: 10.1039/c2dt32055j.

Abstract

A new BODIPY-phosphane was synthesized and proved to be a versatile tool for imaging organometallic complexes. It also led to easy access to a new family of theranostics, featuring gold, ruthenium and osmium complexes. The compounds' cytotoxicity was tested on cancer cells, and their cell uptake was followed by fluorescence microscopy in vitro.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Boron Compounds / chemistry*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Coordination Complexes / chemical synthesis
  • Coordination Complexes / chemistry
  • Coordination Complexes / toxicity
  • Gold / chemistry
  • Humans
  • Metals / chemistry*
  • Microscopy, Confocal
  • Osmium / chemistry
  • Phosphines / chemistry*
  • Ruthenium / chemistry

Substances

  • 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene
  • Boron Compounds
  • Coordination Complexes
  • Metals
  • Phosphines
  • Osmium
  • Gold
  • Ruthenium
  • phosphine