Abstract
A series of novel 3-hydroxy vinylboronates which share structural similarities with sphingolipids were synthesized and tested in vitro and in vivo as anticancer agents. The molecules reduced cancer cell survival in vitro by influencing their sphingolipid metabolism. In a cancer model in nude mice the lead compound E7 prevented the development of tumor as long as the treatment period continued. Moreover, it delayed tumor growth after the treatment was finished.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antineoplastic Agents / chemical synthesis
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology
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Apoptosis / drug effects*
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Boronic Acids / chemical synthesis*
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Boronic Acids / chemistry
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Boronic Acids / pharmacology
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Disease Models, Animal
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Humans
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Hydroxylation
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Inhibitory Concentration 50
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Jurkat Cells
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Mice
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Mice, Nude
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Molecular Structure
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Neoplasms / drug therapy*
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Neoplasms / prevention & control
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Sphingolipids* / metabolism
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Vinyl Compounds / chemical synthesis*
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Vinyl Compounds / chemistry
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Vinyl Compounds / pharmacology*
Substances
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Antineoplastic Agents
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Boronic Acids
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Sphingolipids
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Vinyl Compounds