Effect of HP-β-cyclodextrin in the diffusion behaviour of hydrocortisone in aqueous solutions at T=298.15 K

Int J Pharm. 2013 Jan 30;441(1-2):352-5. doi: 10.1016/j.ijpharm.2012.11.021. Epub 2012 Dec 8.

Abstract

Binary (D) and ternary (D(11), D(22), D(12) and D(21)) mutual diffusion coefficients determined by the Taylor dispersion method are reported for two aqueous systems, pure hydrocortisone (HC/H(2)O) and HC plus HP-β-cyclodextrin (HC/HP-βCD/H(2)O), at T=298.15 K. From these data, some thermodynamic information as well as conclusions about the influence of that carbohydrate in the diffusion of this drug are given.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Anti-Inflammatory Agents / chemistry*
  • Diffusion
  • Excipients / chemistry*
  • Hydrocortisone / chemistry*
  • Thermodynamics
  • Water / chemistry
  • beta-Cyclodextrins / chemistry*

Substances

  • Anti-Inflammatory Agents
  • Excipients
  • beta-Cyclodextrins
  • Water
  • 2-Hydroxypropyl-beta-cyclodextrin
  • Hydrocortisone