Solid phase synthesis of peptide hydroxamic acids on poly(ethylene glycol)-based support

Marta Cal; Mariusz Jaremko; Łukasz Jaremko; Piotr Stefanowicz

doi:10.1002/psc.2466

Solid phase synthesis of peptide hydroxamic acids on poly(ethylene glycol)-based support

J Pept Sci. 2013 Jan;19(1):9-15. doi: 10.1002/psc.2466. Epub 2012 Dec 5.

Authors

Marta Cal¹, Mariusz Jaremko, Łukasz Jaremko, Piotr Stefanowicz

Affiliation

¹ Institute Chemistry, University of Wrocław, 50-383, Joliot-Curie 14, Wrocław, Poland.

PMID: 23225761
DOI: 10.1002/psc.2466

Abstract

A novel resin designed for solid-phase synthesis of peptide hydroxamic acids (PHA) combining the trityl linker with poly(ethylene glycol)-based support, ChemMatrix® type, is described. The synthesis of PHA can be performed according to a standard protocol, providing products in excellent purity and reasonable yields.

MeSH terms

Hydroxamic Acids / chemical synthesis*
Hydroxamic Acids / chemistry
Magnetic Resonance Spectroscopy
Peptides / chemistry*
Polyethylene Glycols / chemistry*
Spectrometry, Mass, Electrospray Ionization
Tandem Mass Spectrometry

Substances

Hydroxamic Acids
Peptides
Polyethylene Glycols