Abstract
As many human sensory and cognitive diseases are caused by irreversible damage or loss of certain types of neurons, methodologies aimed at replacement of lost neurons are key to restore lost sensation. Recent advances in generation of ear-cell progenitors, optic-cup structures and cortical neurons from human embryonic stem cells and induced pluripotent stem cells provide versatile tools for modeling human diseases and developing cells for replacement therapies.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cognition
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Cognition Disorders* / metabolism
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Cognition Disorders* / pathology
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Cognition Disorders* / physiopathology
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Cognition Disorders* / therapy
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Embryonic Stem Cells / metabolism*
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Humans
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Induced Pluripotent Stem Cells / metabolism*
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Neurons / metabolism
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Neurons / pathology
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Regeneration*
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Sensation Disorders* / metabolism
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Sensation Disorders* / pathology
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Sensation Disorders* / physiopathology
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Sensation Disorders* / therapy
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Stem Cell Transplantation*