Neuronal morphogenesis: Golgi outposts, acentrosomal microtubule nucleation, and dendritic branching

Tommy L Lewis Jr; Franck Polleux

doi:10.1016/j.neuron.2012.11.019

Neuronal morphogenesis: Golgi outposts, acentrosomal microtubule nucleation, and dendritic branching

Neuron. 2012 Dec 6;76(5):862-4. doi: 10.1016/j.neuron.2012.11.019.

Authors

Tommy L Lewis Jr¹, Franck Polleux

Affiliation

¹ The Scripps Research Institute, Dorris Neuroscience Center, La Jolla, CA 92037-1000, USA.

PMID: 23217734
DOI: 10.1016/j.neuron.2012.11.019

Abstract

In large cells like neurons, how is microtubule polymerization initiated at large distances from the cell body and the main microtubule-organizing center? In this issue of Neuron, Ori-McKenney et al. (2012) demonstrate that Golgi outposts mediate acentrosomal microtubule nucleation and reveal it is crucial for dendrite morphogenesis.

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