Orientational correlations in confined DNA

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Oct;86(4 Pt 1):041802. doi: 10.1103/PhysRevE.86.041802. Epub 2012 Oct 11.

Abstract

We study how the orientational correlations of DNA confined to nanochannels depend on the channel diameter D by means of Monte Carlo simulations and a mean-field theory. This theory describes DNA conformations in the experimentally relevant regime where the Flory-de Gennes theory does not apply. We show how local correlations determine the dependence of the end-to-end distance of the DNA molecule upon D. Tapered nanochannels provide the necessary resolution in D to study experimentally how the extension of confined DNA molecules depends upon D. Our experimental and theoretical results are in qualitative agreement.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Biophysics / methods*
  • Biopolymers / chemistry
  • Computer Simulation
  • DNA / chemistry*
  • Ions
  • Light
  • Models, Statistical
  • Molecular Conformation
  • Monte Carlo Method
  • Nanostructures / chemistry*
  • Nanotechnology / methods
  • Nucleic Acid Conformation
  • Polymers / chemistry

Substances

  • Biopolymers
  • Ions
  • Polymers
  • DNA