Concentrations and spatial distribution of PFOS and PFOA in surface water from East Lake in Wuhan, Hubei, China were studied. The total concentration of PFCs ranged from 31.1 to 237 ng x L(-1), and the mean value was 115 ng x L(-1), revealing lake-wide contamination in East Lake. PFOS and PFOA were detected in all samples with maximum values of 132 ng x L(-1) and 158 ng x L(-1), respectively, whereas the mean values of PFOS and PFOA were 60.4 and 55.0 ng x L(-1), respectively. The highest concentrations of PFOS and PFOA were found in the eastern area of lake, followed by the southern area of lake, and the western and northern areas of East Lake were the least contaminated regions. The specific distribution and composition profile of PFOS and PFOA, and the lack of significant correlation between PFOS and PFOA, suggested that there were various sources of PFCs. The PFOS concentrations at 30 sample sites (63%) were greater than 43 ng x L(-1), which was used to estimate an avian wildlife value for PFOS. The PFOA concentrations at 20 sample sites (42%) were greater than 40 ng x L(-1), which was a health-based guidance level recommended by the State of New Jersey for PFOA.