Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

Kye-Sung Lee; Huimin Zhao; Sherrif F Ibrahim; Natthani Meemon; Laura Khoudeir; Jannick P Rolland

doi:10.1117/1.JBO.17.12.126006

Three-dimensional imaging of normal skin and nonmelanoma skin cancer with cellular resolution using Gabor domain optical coherence microscopy

J Biomed Opt. 2012 Dec;17(12):126006. doi: 10.1117/1.JBO.17.12.126006.

Authors

Kye-Sung Lee¹, Huimin Zhao, Sherrif F Ibrahim, Natthani Meemon, Laura Khoudeir, Jannick P Rolland

Affiliation

¹ University of Rochester, The Institute of Optics, 275 Hutchinson Road, Rochester, New York 14627, USA.

Abstract

We investigate morphological differences in three-dimensional (3-D) images with cellular resolution between nonmelanoma skin cancer and normal skin using Gabor domain optical coherence microscopy. As a result, we show for the first time cellular optical coherence images of 3-D features differentiating cancerous skin from normal skin. In addition, in vivo volumetric images of normal skin from different anatomic locations are shown and compared.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Dermoscopy / methods*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Melanoma / pathology
Microscopy / methods*
Reproducibility of Results
Sensitivity and Specificity
Skin / pathology*
Skin Neoplasms / pathology*
Tomography, Optical Coherence / methods*