Recent developments in the Reformatsky-Claisen rearrangement

Molecules. 2012 Nov 30;17(12):14249-59. doi: 10.3390/molecules171214249.

Abstract

The rearrangement of allyl a-bromoacetates with Zn dust is known as the Reformatsky-Claisen rearrangement. Whereas the Ireland-Claisen rearrangement has been widely used in the synthesis of a diverse range of natural products, the Zn-mediated Reformatsky-Claisen rearrangement has not been utilized so often. In this article, we will provide an overview of recent advances in the Reformatsky-Claisen rearrangement field, including the In-mediated Reformatsky-Claisen rearrangement we have recently developed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetates* / chemical synthesis
  • Acetates* / chemistry
  • Allyl Compounds* / chemical synthesis
  • Allyl Compounds* / chemistry
  • Biological Products / chemical synthesis
  • Biological Products / chemistry
  • Humans
  • Molecular Structure
  • Zinc / chemistry*

Substances

  • Acetates
  • Allyl Compounds
  • Biological Products
  • bromoacetate
  • Zinc