A 56-year-old patient presenting necrotic ulcerations on the right leg was admitted to our Department for physical status deterioration. Clinically suspected diagnosis of pyoderma gangrenosum was confirmed histologically. Considering the association of pyoderma gangrenosum with several systemic diseases, extensive diagnostic evaluation was performed. Colonoscopy showed multiple ulcerations on descendent colon with stenosis of the shorter segment. Histologic examination confirmed the diagnosis of Crohn's disease. After systemic treatment with corticosteroids and wound management with proper wound dressings, complete epithelialization of ulcerations was accomplished.