Prevalence of transmitted HIV-1 drug resistance mutations in children and adolescents in São Paulo, Brazil

Pediatr Infect Dis J. 2012 Dec;31(12):e255-7. doi: 10.1097/INF.0b013e3182684d8e.

Abstract

HIV drug resistance genotype testing, performed on 39 HIV-infected treatment-naive children from 2000 to 2011, identified 5 children (12.8%) with drug resistance mutations: 5.3% to nucleoside reverse transcriptase inhibitors, 5.3% to nonnucleoside reverse transcriptase inhibitors and 7.7% to protease inhibitors. There was a trend for increasing prevalence of drug resistance mutations during the 11-year study period.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Brazil / epidemiology
  • Child
  • Child, Preschool
  • Drug Resistance, Viral*
  • Female
  • Genotype
  • HIV Infections / epidemiology
  • HIV Infections / transmission*
  • HIV Infections / virology*
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • HIV-1 / isolation & purification
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Mutation, Missense*
  • Prevalence