Lipophilic silver nanoparticles and their polymeric entrapment into targeted-PEG-based micelles for the treatment of glioblastoma

Adv Healthc Mater. 2012 May;1(3):342-7. doi: 10.1002/adhm.201100047. Epub 2012 Apr 5.

Abstract

A simple method for the synthesis of lipophilic Ag NPs have been developed. The coated Ag NPs have been entrapped into a FDA-approved and targetable PEG-based polymeric nanoparticles, and this nanocarrier has been conjugated with the peptide chlorotoxin. Uptake experiments have shown a cell-specific recognition of the Ag-1-PNPs-Cltx on U87MG cell lines in comparison to Balb/3T3. The uptake of Ag into the cells was quantified and an interesting cytotoxic effect (IC50 = 45 μM) has been found on glioblastoma cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Drug Carriers / chemistry*
  • Glioblastoma / drug therapy*
  • Glioblastoma / pathology*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / therapeutic use*
  • Nanocapsules / chemistry*
  • Nanocapsules / therapeutic use
  • Nanocapsules / ultrastructure
  • Polyethylene Glycols / chemistry*
  • Silver / administration & dosage*
  • Treatment Outcome

Substances

  • Drug Carriers
  • Nanocapsules
  • Silver
  • Polyethylene Glycols