Abstract
Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Light
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Materials Testing
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Nanocapsules / chemistry*
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Nanocapsules / radiation effects*
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Nanocapsules / ultrastructure
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Particle Size
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Photosensitizing Agents / chemistry*
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Photosensitizing Agents / radiation effects*
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Porosity / radiation effects
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Protoporphyrins / chemistry*
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Protoporphyrins / radiation effects
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Silicon Dioxide / blood*
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Silicon Dioxide / radiation effects*
Substances
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Nanocapsules
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Photosensitizing Agents
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Protoporphyrins
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Silicon Dioxide
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protoporphyrin IX