Cascaded photoinduced drug delivery to cells from multifunctional core-shell mesoporous silica

Adv Healthc Mater. 2012 May;1(3):316-20. doi: 10.1002/adhm.201100033. Epub 2012 Apr 2.

Abstract

Different bioactive molecules are released into living cells from lipid-covered mesoporous silica nanoparticles. The release is triggered by light, as the particles feature covalently attached photosensitizers as membrane-opening agents. It is demonstrated that the particles achieve endosomal escape and that they release their cargo into the cytosol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Light
  • Materials Testing
  • Nanocapsules / chemistry*
  • Nanocapsules / radiation effects*
  • Nanocapsules / ultrastructure
  • Particle Size
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / radiation effects*
  • Porosity / radiation effects
  • Protoporphyrins / chemistry*
  • Protoporphyrins / radiation effects
  • Silicon Dioxide / blood*
  • Silicon Dioxide / radiation effects*

Substances

  • Nanocapsules
  • Photosensitizing Agents
  • Protoporphyrins
  • Silicon Dioxide
  • protoporphyrin IX