Simvastatin-loaded β-TCP drug delivery system induces bone formation and prevents rhabdomyolysis in OVX mice

Adv Healthc Mater. 2013 May;2(5):678-81. doi: 10.1002/adhm.201200342. Epub 2012 Nov 26.

Abstract

Bone formation and regeneration is a prolonged process that requires a slow drug release system to assist in the long-term recovery. A drug-delivery system is developed that allows for the controlled release of simvastin, without exhibiting the side effects associated with high concentrations of simvastatin, and is still capable of inducing constant bone formation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcium Phosphates / chemistry*
  • Delayed-Action Preparations / administration & dosage*
  • Delayed-Action Preparations / chemical synthesis*
  • Diffusion
  • Female
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
  • Mice
  • Osteogenesis / drug effects*
  • Ovariectomy
  • Rhabdomyolysis / pathology
  • Rhabdomyolysis / physiopathology*
  • Rhabdomyolysis / prevention & control*
  • Simvastatin / administration & dosage*
  • Simvastatin / chemistry
  • Treatment Outcome

Substances

  • Calcium Phosphates
  • Delayed-Action Preparations
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • beta-tricalcium phosphate
  • Simvastatin