Abstract
Bone formation and regeneration is a prolonged process that requires a slow drug release system to assist in the long-term recovery. A drug-delivery system is developed that allows for the controlled release of simvastin, without exhibiting the side effects associated with high concentrations of simvastatin, and is still capable of inducing constant bone formation.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcium Phosphates / chemistry*
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Delayed-Action Preparations / administration & dosage*
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Delayed-Action Preparations / chemical synthesis*
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Diffusion
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Female
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage
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Mice
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Osteogenesis / drug effects*
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Ovariectomy
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Rhabdomyolysis / pathology
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Rhabdomyolysis / physiopathology*
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Rhabdomyolysis / prevention & control*
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Simvastatin / administration & dosage*
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Simvastatin / chemistry
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Treatment Outcome
Substances
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Calcium Phosphates
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Delayed-Action Preparations
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Hydroxymethylglutaryl-CoA Reductase Inhibitors
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beta-tricalcium phosphate
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Simvastatin