Aim: Seroprevalence study in Irula tribe of Marakkanam, Tamil Nadu State was carried out for certain bacterial (typhoid, syphilis and leptospirosis) and viral infection (hanta, hepatitis B and human immunodeficiency virus (HIV)).
Result: Highest seroprevalence was observed for leptospirosis (61.1%) followed by, hepatitis B virus surface antigen (11.11%), syphilis (9.72%), typhoid (8.33%), hantavirus (6.9%) and HIV (2.77%).
Observation: The seroprevalence of leptospirosis and hantavirus may be attributed to their professional exposure to rodent that they catch in the open field and the syphilis, hepatitis B and HIV prevalence may be related to their sexual behavior and social customs.