A novel amine receptor based on the binol scaffold functions as a highly effective chiral shift reagent for carboxylic acids

Qingzhu Ma; Minshan Ma; Hongying Tian; Xiaoxia Ye; Hongping Xiao; Lian-hui Chen; Xinxiang Lei

doi:10.1021/ol3027686

A novel amine receptor based on the binol scaffold functions as a highly effective chiral shift reagent for carboxylic acids

Org Lett. 2012 Dec 7;14(23):5813-5. doi: 10.1021/ol3027686. Epub 2012 Nov 21.

Authors

Qingzhu Ma¹, Minshan Ma, Hongying Tian, Xiaoxia Ye, Hongping Xiao, Lian-hui Chen, Xinxiang Lei

Affiliation

¹ College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, P. R. China.

PMID: 23170807
DOI: 10.1021/ol3027686

Abstract

A "smart" receptor has been newly synthesized. NMR studies demonstrated that the receptor functions as a chiral shift reagent that is highly effective for determining the enantiomeric purity of a series of carboxylic acids, particularly those that have an α-oxygen atom.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carboxylic Acids / chemistry*
Indicators and Reagents
Magnetic Resonance Spectroscopy
Molecular Structure
Naphthols / chemistry*
Oxygen / chemistry

Substances

BINOL, naphthol
Carboxylic Acids
Indicators and Reagents
Naphthols
Oxygen