An efficient single-enzymatic cascade for asymmetric synthesis of chiral amines catalyzed by ω-transaminase

Chem Commun (Camb). 2013 Jan 7;49(2):161-3. doi: 10.1039/c2cc37232k. Epub 2012 Nov 20.

Abstract

An efficient single-enzymatic cascade approach for the asymmetric synthesis of chiral amines has been developed, which applies the amino donor 3-aminocyclohexa-1,5-dienecarboxylic acid spontaneously tautomerizing to reach reaction completion with excellent ee values.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amination
  • Amines / metabolism*
  • Biocatalysis
  • Chromobacterium / enzymology
  • Cyclohexanecarboxylic Acids / chemistry
  • Cyclohexenes / chemistry
  • Stereoisomerism
  • Transaminases / metabolism*

Substances

  • Amines
  • Cyclohexanecarboxylic Acids
  • Cyclohexenes
  • isogabaculine
  • Transaminases