Abstract
Cochinchinenone has been synthesized in only five steps and four pots and in 58% overall yield from commercially available 2,3-dimethoxy-4-hydroxy-benzaldehyde and OPMB-protected p-hydroxy acetophenone, the key step being the oxone-mediated oxidative dearomatization of the corresponding ketone-containing p-substituted phenol.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Biological Products / isolation & purification
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Biological Products / pharmacology
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Catalysis
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Chalcones / chemical synthesis*
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Chalcones / chemistry
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Chalcones / isolation & purification
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Chalcones / pharmacology
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Helicobacter pylori / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Anti-Bacterial Agents
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Biological Products
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Chalcones
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cochinchinenone