MDR1 in paroxetine-induced sexual dysfunction

J Sex Marital Ther. 2013;39(1):71-8. doi: 10.1080/0092623X.2012.668514.

Abstract

Paroxetine-induced sexual dysfunction represents a frequent treatment complication of otherwise efficient antidepressants. The genetic polymorphism of pharmacokinetic genes may contribute to the occurrence of such dysfunctions. This study presents the effect of MDR1 gene polymorphisms on sexual function in 18 women with bulimia nervosa, 18 women with anxiety disorders, and 19 healthy control subjects. It also deals with the relation between MDR1 gene polymorphisms and paroxetine-induced sexual dysfunction. The results demonstrated that MDR1 G2677T/A gene polymorphism allele carriers treated with paroxetine presented with difficulties with orgasm (p = .008) and lubrication (p < .001).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1 / genetics*
  • Adult
  • Antidepressive Agents, Second-Generation / administration & dosage*
  • Anxiety Disorders / drug therapy*
  • Anxiety Disorders / genetics
  • Bulimia Nervosa / drug therapy*
  • Bulimia Nervosa / genetics
  • Case-Control Studies
  • Female
  • Humans
  • Middle Aged
  • Mutation / genetics
  • Polymorphism, Genetic*
  • Sexual Dysfunctions, Psychological / chemically induced*
  • Sexual Dysfunctions, Psychological / genetics
  • Young Adult

Substances

  • ABCB1 protein, human
  • ATP Binding Cassette Transporter, Subfamily B
  • ATP Binding Cassette Transporter, Subfamily B, Member 1
  • Antidepressive Agents, Second-Generation