Direct sp3 C-H amination of nitrogen-containing benzoheterocycles mediated by visible-light-photoredox catalysts

Chemistry. 2012 Dec 14;18(51):16473-7. doi: 10.1002/chem.201203066. Epub 2012 Nov 13.

Abstract

Visible-light-mediated direct sp(3) C-H amination of benzocyclic amines via α-aminoalkyl radicals by using photoredox catalysts is described here. The obtained N,N-acetals were also successfully applied for carbon-carbon bond forming reactions with carbon nucleophiles. The procedure is suitable for a late-stage modification of C-H bonds to C-C bonds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetals / chemistry*
  • Amination
  • Catalysis
  • Heterocyclic Compounds / chemistry*
  • Hydrogen Bonding
  • Light
  • Molecular Structure
  • Nitrogen / chemistry*
  • Photochemical Processes

Substances

  • Acetals
  • Heterocyclic Compounds
  • Nitrogen