Abstract
Two new degraded diterpenoids, trigohowilols A (1) and B (2), four new heterodimers, trigohowilols C-F (3-6), one new homodimer, trigohowilol G (7), and three known degraded diterpenoids (8-10) were isolated from the methanol extract of the stems of Trigonostemon howii. Compounds 1-7 were evaluated for their cytotoxic activity against five human tumor cell lines by an MTT assay, and trigohowilols E (5) and F (6) exhibited inhibitory activity with IC50 values ranging from 2.33 to 12.57 μM. Moreover, compounds 1-6 showed weak antimicrobial activities (MIC values: 6.25-25 μg/mL) against Staphylococcus aureus, Pseudomonas aeruginosa, MRSA 92(#), and MRSA 98(#) using a 2-fold dilution method.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Bacterial Agents / isolation & purification*
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Anti-Bacterial Agents / metabolism
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Anti-Bacterial Agents / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Diterpenes / isolation & purification*
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Diterpenes / metabolism
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Diterpenes / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Euphorbiaceae / chemistry*
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Humans
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Methicillin-Resistant Staphylococcus aureus / drug effects
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Microbial Sensitivity Tests
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
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Plant Stems / chemistry
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Pseudomonas aeruginosa / drug effects
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Staphylococcal Infections / drug therapy
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Staphylococcus aureus / drug effects
Substances
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Anti-Bacterial Agents
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Antineoplastic Agents, Phytogenic
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Diterpenes
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Drugs, Chinese Herbal
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trigohowilol E
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trigohowilol F