The prevalence of human cytomegalovirus DNA in gliomas of Brazilian patients

Mem Inst Oswaldo Cruz. 2012 Nov;107(7):953-4. doi: 10.1590/s0074-02762012000700020.

Abstract

Members of the Herpesviridae family have been implicated in a number of tumours in humans. At least 75% of the human population has had contact with cytomegalovirus (HCMV). In this work, we screened 75 Brazilian glioma biopsies for the presence of HCMV DNA sequences. HCMV DNA was detected in 36% (27/75) of the biopsies. It is possible that HCMV could be a co-factor in the evolution of brain tumours.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biopsy
  • Brain Neoplasms / virology*
  • Child
  • Cohort Studies
  • Cytomegalovirus / genetics*
  • Cytomegalovirus / immunology
  • Cytomegalovirus Infections / complications*
  • Cytomegalovirus Infections / diagnosis
  • DNA, Viral / analysis*
  • Female
  • Glioma / virology*
  • Humans
  • Immediate-Early Proteins / analysis
  • Immediate-Early Proteins / immunology
  • Male
  • Neoplasm Staging
  • Polymerase Chain Reaction
  • Prevalence
  • Young Adult

Substances

  • DNA, Viral
  • IE1 protein, cytomegalovirus
  • Immediate-Early Proteins