Abstract
Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Drug Resistance, Fungal
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Gene Deletion
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Gold / toxicity*
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Metabolic Networks and Pathways*
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Microbial Viability / drug effects
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Nanoparticles / toxicity*
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Saccharomyces cerevisiae / drug effects*
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Saccharomyces cerevisiae / genetics*
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Saccharomyces cerevisiae / physiology