Abstract
Striking cAMP: certain fatty acid amides from marine cyanobacteria can mimic the endocannabinoids. Serinolamide B, a new analogue identified from a Guamanian sample, and malyngamide B, a representative member of a large class of cyanobacterial metabolites, can decrease forskolin-induced cAMP accumulation through the cannabinoid receptors.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Amides / chemistry*
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Animals
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Aquatic Organisms / chemistry*
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Biomimetic Materials / chemistry
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Biomimetic Materials / pharmacology
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Cannabinoid Receptor Agonists / chemistry
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Cannabinoid Receptor Agonists / pharmacology
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Cannabinoid Receptor Antagonists / chemistry
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Cannabinoid Receptor Antagonists / pharmacology
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Cell Survival / drug effects
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Cyanobacteria / chemistry*
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Fatty Acids / chemistry*
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Fatty Acids / pharmacology*
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HT29 Cells
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Humans
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MCF-7 Cells
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Mice
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Receptors, Cannabinoid / metabolism*
Substances
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Amides
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Cannabinoid Receptor Agonists
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Cannabinoid Receptor Antagonists
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Fatty Acids
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Receptors, Cannabinoid