Marine cyanobacterial fatty acid amides acting on cannabinoid receptors

Chembiochem. 2012 Dec 21;13(18):2676-81. doi: 10.1002/cbic.201200502. Epub 2012 Nov 9.

Abstract

Striking cAMP: certain fatty acid amides from marine cyanobacteria can mimic the endocannabinoids. Serinolamide B, a new analogue identified from a Guamanian sample, and malyngamide B, a representative member of a large class of cyanobacterial metabolites, can decrease forskolin-induced cAMP accumulation through the cannabinoid receptors.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amides / chemistry*
  • Animals
  • Aquatic Organisms / chemistry*
  • Biomimetic Materials / chemistry
  • Biomimetic Materials / pharmacology
  • Cannabinoid Receptor Agonists / chemistry
  • Cannabinoid Receptor Agonists / pharmacology
  • Cannabinoid Receptor Antagonists / chemistry
  • Cannabinoid Receptor Antagonists / pharmacology
  • Cell Survival / drug effects
  • Cyanobacteria / chemistry*
  • Fatty Acids / chemistry*
  • Fatty Acids / pharmacology*
  • HT29 Cells
  • Humans
  • MCF-7 Cells
  • Mice
  • Receptors, Cannabinoid / metabolism*

Substances

  • Amides
  • Cannabinoid Receptor Agonists
  • Cannabinoid Receptor Antagonists
  • Fatty Acids
  • Receptors, Cannabinoid