Epidemiology of vancomycin-resistant enterococci with reduced susceptibility to daptomycin

Infect Control Hosp Epidemiol. 2012 Dec;33(12):1250-4. doi: 10.1086/668438. Epub 2012 Oct 25.

Abstract

A retrospective case-case control study was conducted, including 60 cases with daptomycin-nonsusceptible vancomycin-resistant enterococci (DNS-VRE) matched to cases with daptomycin-susceptible VRE and to uninfected controls (1∶1∶3 ratio). Immunosuppression, presence of comorbid conditions, and prior exposure to antimicrobials were independent predictors of DNS-VRE, although prior daptomycin exposure occurred rarely. In summary, a case-case control study identified independent risk factors for the isolation of DNS-VRE: immunosuppression, multiple comorbid conditions, and prior exposures to cephalosporines and metronidazole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Case-Control Studies
  • Cephalosporins / therapeutic use
  • Comorbidity
  • Daptomycin / pharmacology*
  • Drug Resistance, Multiple, Bacterial*
  • Enterococcus faecalis / drug effects*
  • Enterococcus faecium / drug effects*
  • Female
  • Gram-Positive Bacterial Infections / epidemiology*
  • Gram-Positive Bacterial Infections / microbiology
  • Humans
  • Immunosuppression Therapy
  • Male
  • Metronidazole / therapeutic use
  • Middle Aged
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Statistics, Nonparametric
  • Vancomycin / pharmacology*
  • Vancomycin Resistance

Substances

  • Anti-Bacterial Agents
  • Cephalosporins
  • Metronidazole
  • Vancomycin
  • Daptomycin