Does BCG revaccination protect against the development of asthma?

Respir Med. 2013 Feb;107(2):317-9. doi: 10.1016/j.rmed.2012.10.009. Epub 2012 Nov 6.

Abstract

Single BCG vaccination has been considered as a protective factor against asthma. However the effect of a second dose of BCG on the prevalence rate of asthma and asthma-allergic rhinitis-eczema comorbidity has not been studied exclusively among adolescents. In this ISAAC protocol-based cross sectional study we assessed the association between one single versus two doses of BCG among 2213 individuals aged 13-14 years old. We found no association between BCG revaccination and asthma, associated (OR = 0.68, 95% CI, 0.37-1.25) or not to allergic rhinitis and/or atopic eczema (OR = 1.07, 95% CI, 0.84-1.36).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Asthma / epidemiology
  • Asthma / prevention & control*
  • BCG Vaccine*
  • Brazil / epidemiology
  • Cross-Sectional Studies
  • Dermatitis, Atopic / epidemiology
  • Dermatitis, Atopic / prevention & control
  • Humans
  • Immunization, Secondary*
  • Prevalence
  • Rhinitis, Allergic, Perennial / epidemiology
  • Rhinitis, Allergic, Perennial / prevention & control
  • Rhinitis, Allergic, Seasonal / epidemiology
  • Rhinitis, Allergic, Seasonal / prevention & control

Substances

  • BCG Vaccine