Abstract
We investigated the cytotoxicity of the fullerene C60 derivatives. We showed that complexes of C60 fullerene with polyvinylpyrrolidone (m.w. of polyvinylpyrrolidone 10000 and 25000), C60-NO2-proline and C60-alanine had no toxic effect on HEp-2 cells. Sodium salt of polycarboxylic derivative of fullerene C60 exerted a pronounced toxic effect on this cell culture.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alanine / chemistry*
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Cell Line, Tumor
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Cell Survival / drug effects
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Fullerenes / chemistry*
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Fullerenes / pharmacology
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Humans
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Molecular Weight
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Povidone / chemistry*
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Proline / chemistry*
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Salts
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Sodium / chemistry
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Solubility
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Structure-Activity Relationship
Substances
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Fullerenes
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Salts
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Proline
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Sodium
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Povidone
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fullerene C60
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Alanine