Aptamer-functionalized, ultra-small, monodisperse silica nanoconjugates for targeted dual-modal imaging of lymph nodes with metastatic tumors

Angew Chem Int Ed Engl. 2012 Dec 14;51(51):12721-6. doi: 10.1002/anie.201205271. Epub 2012 Nov 7.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Aptamers, Nucleotide / chemistry*
  • Breast Neoplasms / diagnostic imaging
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Female
  • Humans
  • Lymph Nodes / diagnostic imaging*
  • Lymphatic Metastasis
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Multimodal Imaging
  • Nanoconjugates / chemistry*
  • Nanoconjugates / ultrastructure
  • Positron-Emission Tomography
  • Rhodamines / chemistry
  • Silicon Dioxide / chemistry*
  • Spectroscopy, Near-Infrared
  • Tomography, X-Ray Computed
  • Transplantation, Heterologous

Substances

  • Aptamers, Nucleotide
  • Nanoconjugates
  • Rhodamines
  • Silicon Dioxide
  • rhodamine isothiocyanate