Objective: To investigate the effects of dexmedetomidine combined with fentanyl in patients undergoing anesthesia induction by sevoflurane.
Method: Eighty patients for elective endotracheal intubation under general anesthesia operations were randomly and double-blindly divided into Dex combined with fentanyl group (Group DF) and the fentanyl group (Group F) from April 2011 to September 2011 at the Fourth Affiliated Hospital of Harbin Medical University, and there were 40 cases in each group. The investigation was approved by all the patients and by the Ethics Committee of the hospital. In group DF, each patient was pumped in the 0.5 µg/kg Dex by vein before 10 minutes of anesthesia induction and group F were given the same amount of normal saline, and tidal volume method was used to induce anesthesia of sevoflurane. All the patients were given 2 µg/kg fentanyl and 0.1 mg/kg vecuronium by tracheal intubation and the MAP and HR and adverse reactions were observed before anesthesia induction (T(0)), before endotracheal intubation (T(1)), at the moment of tracheal intubation (T(2)), after 1 minutes of tracheal intubation (T(3)), after 3 minutes of tracheal intubation (T(4)) and after 5 minutes of tracheal intubation (T(5)).
Result: The loss of eyelash reflex time of group DF is shorter (P < 0.05), adverse reaction is less (P < 0.05) and the number of adding atropine case is higher than that of group F (P < 0.05), the MAP of the two groups after induction of other moments are lower than that of T(0) (P < 0.05); MAP of group F at T(1) is lower than that of T(0), T(2), T(3) and group DF (P < 0.05); T(1) of group DF is lower than that of T(0) (P < 0.05), the HR after induction of group DF is lower than that of T(0) and F group (P < 0.05), and that of T(2) and T(4) are higher than that of T(1) (P < 0.05); HR of group F at T(1) is lower than that of T(2) and T(3) (P < 0.05).
Conclusion: Dexmedetomidine in combination with fentanyl can inhibit stress response of tracheal intubation of sevoflurane induction efficiently and stabilize hemodynamics.