Although the description of the PTSD clinical picture dates from history, our professional community has known for about two decades. PTSD is clearly defined in the 10th International Classification of Diseases, World Health Organization and IV Diagnostic Statistical Manual of Mental Disorders. Together with panic disorder, agoraphobia, specific and social phobias, obsessive-compulsive disorder and generalized anxiety disorder is one of the large groups of anxiety disorders. A superficial approach, we could conclude that in the relation with PTSD is all clear. It was also found that PTSD is often associated with depression, anxiety disorders, and excessive drinking, substance abuse, and personality disorder, dissociative and other disorders. It is true that our knowledge of PTSD from year to year is larger and larger. However, regarding PTSD, there are many uncertainties, doubts and controversies. Is PTSD a disorder, illness, rent or a passing phase in the development of various diseases? In recent years, there are many studies that are trying to illuminate different aspects of PTSD. Numerous clinical, neurobiological, psycho physiological and MR volumetric studies indicate many uncertainties related to PTSD. About psychotic PTSD is more frequently discussed and written. Whether PTSD is or its symptoms or complications during periods of decompensation may have the character of the psychosis and the psychosis within PTSD or a co-morbid diagnosis? It is certain that about PTSD there are many uncertainties and doubts, that the investigation should continue and that PTSD is a paradigm for new psychiatry.