Formation of SERS active nanoparticle assemblies via specific carbohydrate-protein interactions

Derek Craig; Jonathan Simpson; Karen Faulds; Duncan Graham

doi:10.1039/c2cc36949d

Formation of SERS active nanoparticle assemblies via specific carbohydrate-protein interactions

Chem Commun (Camb). 2013 Jan 4;49(1):30-2. doi: 10.1039/c2cc36949d. Epub 2012 Oct 31.

Authors

Derek Craig¹, Jonathan Simpson, Karen Faulds, Duncan Graham

Affiliation

¹ Centre for Molecular Nanometrology, WestCHEM, Pure and Applied Chemistry, University of Strathclyde, 295 Cathedral Street, Glasgow, G1 1XL, UK.

PMID: 23114655
DOI: 10.1039/c2cc36949d

Abstract

An on/off SERS aggregation system has been designed to investigate carbohydrate-lectin interactions. Detection of the lectin ConA was achieved at pico molar levels. Discrimination was also demonstrated between two different carbohydrate moieties demonstrating the specific interaction between the carbohydrate and specific protein present.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrates / chemistry
Concanavalin A / chemistry*
Concanavalin A / metabolism
Galactose / chemistry
Lactose / chemistry
Lectins / chemistry*
Lectins / metabolism
Nanoparticles / chemistry*
Spectrum Analysis, Raman

Substances

Carbohydrates
Lectins
Concanavalin A
Lactose
Galactose