Corticosteroid therapy in genotype ST-11 meningococcal infections

Pediatr Infect Dis J. 2013 Mar;32(3):291-3. doi: 10.1097/INF.0b013e31827b12cb.

Abstract

Corticosteroid treatment for meningococcal disease is debated. We report a high risk of death (odds ratio 4.68, 95% confidence interval: 1.91-11.46; P = 0.001) without corticosteroid treatment when meningococcal disease is provoked by isolates belonging to the hyperinvasive genotype ST-11. Genotypes of meningococcal isolates should be considered with corticosteroids therapy for meningococcal disease.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use*
  • Anti-Inflammatory Agents / therapeutic use*
  • Child
  • Child, Preschool
  • Female
  • Genotype
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Meningococcal Infections / drug therapy*
  • Meningococcal Infections / microbiology
  • Meningococcal Infections / mortality*
  • Neisseria meningitidis / classification
  • Neisseria meningitidis / genetics
  • Neisseria meningitidis / isolation & purification
  • Survival Analysis

Substances

  • Adrenal Cortex Hormones
  • Anti-Inflammatory Agents