Neurogenesis enhancer RO 25-6981 facilitates repeated spatial learning in adult rats

Bull Exp Biol Med. 2012 Sep;153(5):764-6. doi: 10.1007/s10517-012-1821-6.

Abstract

The effects of Ro 25-6981 (selective NMDA receptor blocker) in a dose stimulating neurogenesis on repeated learning, reversal learning, and memory reconsolidation were studied in adult rats in Morris water maze. Ro 25-6981 facilitated repeated learning 13 days after injection, but did not influence reversal learning. The blocker injected directly before reminder did not disturb repeated learning and reversal learning in Morris water maze. These effects of Ro 25-6981 on the dynamics of repeated learning seemed to be due to its effects on neurogenesis processes in adult brain.

MeSH terms

  • Animals
  • Learning / drug effects*
  • Learning / physiology
  • Male
  • Maze Learning / drug effects
  • Memory, Long-Term / drug effects*
  • Memory, Long-Term / physiology
  • Neurogenesis / drug effects*
  • Neurogenesis / physiology
  • Phenols / pharmacology*
  • Piperidines / pharmacology*
  • Rats
  • Rats, Wistar
  • Space Perception / drug effects*
  • Space Perception / physiology
  • Statistics, Nonparametric

Substances

  • Phenols
  • Piperidines
  • Ro 25-6981