The study of candidate genes related to the neurodevelopmental hypothesis of anorexia nervosa: classical association study versus decision tree

Psychiatry Res. 2013 Mar 30;206(1):117-21. doi: 10.1016/j.psychres.2012.09.005. Epub 2012 Oct 27.

Abstract

In this research, we conducted a study of genes connected with the neurodevelopmental hypothesis of anorexia nervosa, using classical statistical and data-mining methods to establish a relationship with disease risk and algorithms to identify the best genetic predictors of anorexia nervosa.

MeSH terms

  • Adolescent
  • Algorithms
  • Anorexia Nervosa / genetics*
  • Brain-Derived Neurotrophic Factor / genetics
  • Databases, Factual / statistics & numerical data
  • Decision Trees*
  • Epistasis, Genetic
  • Female
  • Genetic Association Studies
  • Genotype
  • Humans
  • Linkage Disequilibrium
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Proto-Oncogene Proteins c-fyn / genetics
  • Receptor, trkB / genetics
  • Regression Analysis
  • Young Adult

Substances

  • Brain-Derived Neurotrophic Factor
  • Receptor, trkB
  • FYN protein, human
  • Proto-Oncogene Proteins c-fyn