Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum

Fitoterapia. 2013 Jan:84:54-7. doi: 10.1016/j.fitote.2012.10.013. Epub 2012 Oct 24.

Abstract

An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H(2)O(2)/Aβ(25-35) induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC(50) of 32.6μM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alkaloids / chemistry*
  • Alkaloids / pharmacology*
  • Animals
  • Models, Molecular
  • Molecular Structure
  • Neuroprotective Agents / chemistry*
  • Neuroprotective Agents / pharmacology*
  • PC12 Cells
  • Plant Roots / chemistry*
  • Rats
  • Sinomenium / chemistry*

Substances

  • Alkaloids
  • Neuroprotective Agents
  • sinoscrewtine