Relaxivity control of magnetic nanoclusters for efficient magnetic relaxation switching assay

Chem Commun (Camb). 2013 Jan 18;49(5):457-9. doi: 10.1039/c2cc36863c.

Abstract

50 nm Magnetic nanocluster (MNC) was deliberately selected as an efficient probe for the magnetic relaxation switching (MRSw) assay. After surface modification of MNCs with poly(acrylic acid) to give PAA-MNCs, and employing streptavidin-biotin interactions for the MRSw assay model, a few tenths pM concentration of strepavidin could be determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylic Resins / chemistry
  • Biotin / metabolism
  • Chlorides / chemistry
  • Ethylene Glycol / chemistry
  • Ferric Compounds / chemistry
  • Magnetics*
  • Magnetite Nanoparticles / chemistry*
  • Magnetite Nanoparticles / ultrastructure
  • Streptavidin / analysis
  • Streptavidin / metabolism

Substances

  • Acrylic Resins
  • Chlorides
  • Ferric Compounds
  • Magnetite Nanoparticles
  • carbopol 940
  • Biotin
  • Streptavidin
  • Ethylene Glycol
  • ferric chloride